The consulate was established in November 1818

The following consuls succeeded each other in the period:

• Antonio Beramendi, former Spanish consul in Genoa (November 1818 - October 1823)
• Giuseppe Oneto, (October 1823- June 1839) consul (October 1823) then consul general in January 1834
• Francesco Oneto (June 1839 - December 1847)

Vice consul in Genoa in the long period 1823 - 1847 is Luigi Oneto.

The vice consuls of the two Rivieras also depend on the Consulate:

• Giacomo Gemelli, in Portofino (from October 1823)
• Pantaleo Prasca, in Sestri Levante (from before 1823)
• Francesco Vissej, Portovenere (from before 1823)
• Carlo Compareti, in La Spezia (since November 1826)
• Giovanni Battista Mazzi, in Sarzana (from November 1826).
  Mazza at the closing of the Consulate, in 1847, will become vice-consul of the Grand Duchy of Tuscany in that same post
• Carlo Boggiano, in Alassio (from before 1823)
• Giovanni Battista Estarico, in Nice, from August 1829

The consular office in Genova was in Piazza Rovere, 307

The consulate general of the Grand Duchy of Tuscany in Genoa is one of the oldest Grand Ducal consulates.
In the period 1814-1860 the following consuls and regents succeeded each other:

• Francesco Bocci, provisional consul, later consul general (1814-1828)
• Fedele Quaglia, regent of the Consulate (1828-1829)
• Alessandro Scacerni, consul general (1829-1833)
• Carlo Pietro Cecconi, in charge of the Consulate then consul general (from 1833)

Vice consular dependencies:

• Finale (since 1819),
• Lerici (since 1850)
• Portofino (since 1816)
• Portovenere (since 1853)
• San Pier d’Arena (since 1857)
• Sarzana (since 1847)
• Savona (since 1816)
• Sestri di Levante (since 1857)
• Spezia (since 1815)